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COVID-19 vaccine 90% effective in Phase 3 trial, says Pfizer

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A vaccine jointly developed by Pfizer and BioNTech was 90 percent effective in preventing Covid-19 infections in ongoing Phase 3 trials, the companies announced Monday.

The statement was released as soaring coronavirus cases across the world have forced many millions of people back into lockdown, causing further damage to ravaged economies.

European stock markets and oil prices jumped on the announcement.

And US President Donald Trump, who lost last week’s election in part over his administration’s response to the pandemic, hailed the announcement as “such great news”.

According to preliminary findings, protection in patients was achieved seven days after the second of two doses, and 28 days after the first.

The companies said they expect to supply up to 50 million vaccine doses globally in 2020, and up to 1.3 billion doses in 2021.

“The first set of results from our Phase 3 Covid-19 vaccine trial provides the initial evidence of our vaccine’s ability to prevent Covid-19,” Pfizer Chairman and CEO Albert Bourla said in a statement.

“We are a significant step closer to providing people around the world with a much-needed breakthrough to help bring an end to this global health crisis,” he said.

“We are reaching this critical milestone in our vaccine development program at a time when the world needs it most.”

– Seeking emergency use authorization –
Across much of the globe, Covid-19 infections rates are hitting record highs, with hospital intensive care units filling up and death tolls mounting.

US biotech firm Moderna, several state-run Chinese labs, and a European project led by the University of Oxford and AstraZeneca are also thought to be closing in on potentially viable vaccines.

Two Russian Covid-19 vaccines have been registered for use even before clinical trials were completed, but have not been widely accepted outside of Russia.

The Phase 3 clinical trial — the final stage — of the new vaccine, BNT162b2, began in late July and has enrolled 43,538 participants to date, 90 percent of whom have received a second dose of the vaccine candidate as of November 8.

Pfizer said it is gathering two months of safety data following the final dose — a requirement of the US Food and Drug Administration — to qualify for Emergency Use Authorization, which it expects by the third week in November.

“We look forward to sharing additional efficacy and safety data generated from thousands of participants in the coming weeks,” Bourla said.

– ‘Watershed moment’ –
While the Pfizer-BioNTech trial has yet to be peer-reviewed by experts, scientists reacted positively — if cautiously to the results.

Michael Head, Senior Research Fellow in Global Health, University of Southampton, called it an “excellent result for a first-generation vaccine”.

Peter Horby, Professor of Emerging Infectious Diseases and Global Health in the Nuffield Department of Medicine, University of Oxford, said Pfizer’s announcement “feels to me like a watershed moment” in the pandemic.

But others pointed out that there would likely be significant logistical problems in getting the vaccine to everyone, especially given it must be kept super-cooled and currently requires two doses to bestow immunity.

Eleanor Riley, professor of Immunology and Infectious Disease at the University of Edinburgh, said for example that Monday’s results did not disclose the ages of participants.

“If a vaccine is to reduce severe disease and death, and thus enable the population at large to return to their normal day-to-day lives, it will need to be effective in older and elderly members of our society,” she said.

– Dozens more candidates –
The so-called messenger RNA, or mRNA, vaccine is a new approach to protecting against viral infection.

Unlike traditional vaccines, which work by training the body to recognize and kill proteins produced by pathogens, mRNA tricks the patient’s immune system to produce viral proteins itself.

The proteins are harmless, but sufficient to provoke a robust immune response.

The study also will evaluate the potential for the vaccine candidate to provide protection against COVID-19 in those who have had prior exposure to SARS-CoV-2, as well as vaccine prevention against severe COVID-19 disease.

Pfizer and BioNTech plan to submit data from the full Phase 3 trial for scientific peer-review publication.

As of mid-October, the World Health Organization (WHO) has identified 42 “candidate vaccines” at the stage of clinical trials, up from 11 in mid-June.

Ten of them were at the most advanced phase 3 stage, in which a vaccine’s effectiveness is tested on a large scale, generally tens of thousands of people across several continents.

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There’s Political Genocide Against Christians in Northern Nigeria – Aisha Yesufu

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By: Fabian Apechihin

Sociopolitical activist Aisha Yesufu has accused Nigerian political leaders of perpetuating what she described as a “political genocide” against Christians in Northern Nigeria.

Yesufu made the remark on Tuesday in response to American comedian and TV host Bill Maher, who recently alleged that Nigerian Christians are facing coordinated attacks.

Maher, speaking on his HBO show, said, “I’m not a Christian, but they are systematically killing Christians in Nigeria. They’ve killed over 100,000 since 2009 and burned 18,000 churches. These are the Islamists, Boko Haram.”

Reacting via her X handle, Yesufu criticized what she called hypocrisy among Nigerian politicians who express concern over Christian persecution yet supported the Muslim-Muslim presidential ticket during the 2023 elections.

“You are shouting that Northern Christians are being persecuted, but you championed a Muslim-Muslim ticket! Their Christianity was not Christian enough for you during the 2023 election,” she wrote.

She concluded by calling for greater attention to what she termed the “political genocide” against Northern Christians, urging consistency in both words and actions when addressing religious and political marginalization in Nigeria.

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Jagunmolu to Kwarans: Don’t lose hope in govt on security challenges

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Stephen Olufemi Oni, Ilorin

The Jagunmolu and Asiwaju of Igbomina, Alhaji Chief (Dr) Abdur-Raheem Oladimeji, has expressed optimism that the rising insecurity in parts of Kwara State would not overwhelm the state.

He identified the incidences of banditry and kidnapping for ransom as a passing phase, which was designed by unscrupulous elements to destabilise Kwara.

Oladimeji, who is the Founder, Al-Hikmah University, Ilorin and Baba Oba of Offa Kingdom, said this in a statement issued in Ilorin on Monday in response to the recent security breaches in some communities in Kwara North and Kwara South.

He urged the residents of affected communities, and Kwarans at large, not to lose hope in the ability of the government and security agencies to tame the roughnecks and restore peace to their communities.

The Arogundade of Lagos described the terror campaign as an unconventional warfare that requires tactics and wisdom on the part of the military to tackle, pointing out that the attackers often cowardly withdraw to their shells after visiting attacks on their victims.

He cautioned those who are out to profit from the ruins of the affected communities by making mockery of the situation with reckless comments to stop forthwith.

Oladimeji also warned against scaremongering being created over the security challenge, urging vigilance and making useful information available to security agencies on any strange movements in their communities.

“Let us be wary of scaremongers, who have made it their daily habit to create imaginary fear as a result of which people are thrown into panic mode. That there is security breach has not been denied. However, we need to be careful and circumspect on the information unauthorized individuals circulate on the issue of insecurity,” the varsity founder noted.

Jagunmolu, who doubles as President-General, AROIF, appealed for calm, unity, security consciousness, while commending the government for its proactive intervention to rout out the unscrupulous element.

He praised the gallantry of military personnel and other security operatives, calling for words of encouragement among the people to boost the morale of the armed personnel.

Oladimeji sympathised with the families of those who lost their loved ones in the recent tragedy and called for additional deployment of security personnel to troubled areas for quick restoration of permanent peace.

“We need to pray for peace and justice to return to Igbomina land, Kwara and the entire country so that we can overcome our moment of trial and tribulation. Our people should take it as a matter of duty to report strange movements to the security agencies and constituted authorities,” Jagunmolu added.

END.

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Northern Christians Urge Tinubu to Resettle Displaced Persons in Benue, Plateau, Borno

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By: Fabian Apechihin

Northern Christian leaders have appealed to President Bola Ahmed Tinubu to urgently resettle displaced persons in Benue, Plateau, and Borno States, many of whom have remained in camps within and outside Nigeria years after violent attacks forced them from their ancestral homes.

The appeal was made in Jos, Plateau State, during a meeting with the President, which clerics described as a renewed opportunity to highlight the plight of displaced communities in Northern Nigeria. The leaders were in Jos to attend the funeral of Mama Lydia Yilwata, mother of Prof. Nentawe Yilwata, National Chairman of the All Progressives Congress (APC).

Speaking on behalf of the delegation, Rev. Dr Amos M. Mohzo, President of the Church of Christ in Nations (COCIN) and Chairman of the Heads of Denominational Leaders on the Plateau, lamented that more than 200,000 people from Gwoza in Borno State still remain in refugee camps in Cameroon and Chad.

“We humbly appeal to you, Mr President, to help bring them back home. In the same vein, we are calling for a lifeline for displaced communities in Plateau and Benue States. Rebuilding their livelihoods and housing will reposition them for meaningful life and productivity,” Mohzo said.

He commended the President’s efforts to strengthen national security and support for state police, stressing that resettling displaced families was critical for peace and stability in the North. Mohzo also thanked Tinubu for key appointments of Northern Christians—including Senator George Akume as Secretary to the Government of the Federation, General Christopher Musa as Chief of Defence Staff, and Prof. Nentawe Yilwata as APC National Chairman—and urged broader inclusion of Christians in governance.

Similarly, Rev. Joseph John Hayab, Chairman of the Christian Association of Nigeria (CAN) in Northern Nigeria, reinforced the call, urging Tinubu to establish a Special Presidential Reconstruction Initiative to rebuild homes, restore livelihoods, and provide social infrastructure for displaced families.

“Our people cannot continue to live in camps when their ancestral homes have been taken over. We are appealing to Mr President to act with urgency so that these Nigerians can return home and live meaningful lives again,” Hayab said.

The clerics pledged continued commitment to peace and national unity, assuring the President of their support for policies that promote justice, inclusivity, and human dignity. They also extended condolences to Prof. Yilwata, the Ngas nation, and the people of Plateau State over the loss of Mama Lydia Yilwata.

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